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KMID : 0369820090390010007
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 1 p.7 ~ p.12
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Dissolution Rate Improvement of Tinidazole Tablets using PEO and HPMC
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Kim Kyung-Joo
Kang Chin-Yang
Choi Jong-Seo
Hwang Chang-Hwan
Park Jun-Bom
Lee Joeng-Sig
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Abstract
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A novel polymeric tablet of Tinidazole was formulated to treat Helicobacter pylori and Giardia lambria more efficiently, It was possible to reduce hepatotoxicity by controlling the release of Tinidazole after peroral administration. A gastric retentive formulation made of naturally occurring carbohydrate polymers and containing Tinidazole was tested in vitro for swelling and dissolution characteristics. Tinidazole tablets containing various concentration of either PEO or HPMC were prepared by the wet granulation method. In vitro release of Tinidazole at pH 1.2 and pH 6.8 buffer solutions was observed at by using a KP dissolution method and an UV (313 nm) spectrophotometer. Compared to a commercial Tinidazole tablet, in vitro release of Tinidazole at both pH 1.2 and pH 6.8 buffer solutions significantly decreased as the concentration of PEO or HPMC in the tablet increased up. And the gastric retentive formulation hydrated and swelled back to about 50% of its original size in 30 min. Thus, it was possible to control the release of Tinidazole by changing the content of PEO or HPMC in the tablet, thereby manipulating the release rate and the retention of Tinidazole.
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KEYWORD
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Gastric retention, Tinidazole, Polyethylene oxide, PEO, Hydroxy propyl methyl cellulose, HPMC
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